This guidance note aims to provide practical support to service providers operating Women and Girls Safe Spaces (WGSS) on how to adapt programming in the context of the COVID-19 pandemic. This note includes six sections: 1) criticality of WGSS; 2) meeting WGSS standard objectives; 3) applying WGSS guiding principles; 4) mainstreaming attention to key concerns; 5) recommended WGSS Interventions, Adaptations, and Safety Measures across different phases/risk levels; and 6) key advocacy points.